AI & Technology
14 CompaniesOpenAI
AI Research & Deployment
Creator of ChatGPT and GPT models. World's most valuable AI company, raising $40B in 2025 - the largest venture round ever recorded.
openai.com →Anthropic
AI Safety & Research
Creator of Claude AI. Raised $13B Series F in 2025, focused on developing safe and beneficial AI systems with Constitutional AI approach.
anthropic.com →Anysphere (Cursor)
AI-Powered Code Editor
Raised $2.3B at $29.3B valuation. AI code assistant used by OpenAI, Uber, Spotify, and Instacart engineers worldwide.
cursor.sh →Safe Superintelligence (SSI)
AI Safety Research
Co-founded by former OpenAI chief scientist. Raised $2B in 2025, valued at $32B. Focused on developing safe superintelligent AI.
ssi.inc →Thinking Machines Lab
AI Research Lab
Founded by former OpenAI CTO Mira Murati. Raised $2B seed round - the largest seed round ever recorded - led by Andreessen Horowitz.
thinkingmachines.ai →LangChain
AI Development Framework
Open-source framework for developing applications powered by language models. Essential infrastructure for AI application development.
langchain.com →Perplexity AI
AI-Powered Search Engine
AI-powered answer engine that provides accurate, sourced answers. One of the fastest-growing AI companies in San Francisco.
perplexity.ai →Databricks
Data & AI Platform
Unified analytics platform bridging data science, engineering, and business intelligence. Expected IPO at $43B+ valuation.
databricks.com →Intuitive Surgical
Robotic Surgery Pioneer
Maker of the Da Vinci Surgical System. 15,600+ employees, $6B+ annual revenue. Pioneer in robotic-assisted minimally invasive surgery.
intuitive.com →Neuralink
Brain-Computer Interface
Developing brain-computer interface devices to assist people with paralysis and blindness, with potential to expand human capabilities.
neuralink.com →Scale AI
Data Platform for AI
Leading data infrastructure company powering the most advanced AI models. Provides training data for OpenAI, Meta, and government agencies.
scale.com →Lambda
AI Cloud Infrastructure
Raised $480M Series D at ~$2.5B valuation. Provides GPU cloud computing infrastructure for AI training and inference.
lambdalabs.com →Groq
AI Inference Chips
Creator of the world's first Language Processing Unit (LPU). Founded by former Google TPU architect Jonathan Ross.
groq.com →Dialpad
AI-Powered Communications
San Francisco-headquartered business communications platform using AI for voice, video, messages, and meetings.
dialpad.com →Biotech & Life Sciences
12 CompaniesGenentech
Birthplace of Biotechnology
Founded 1976 - launched the biotech industry. 13,500+ employees. Now Roche's U.S. pharma HQ, pioneering oncology and immunology treatments.
gene.com →Gilead Sciences
Biopharmaceutical Leader
Global leader in antiviral therapies including HIV/AIDS treatments. Developed groundbreaking hepatitis C cure and COVID-19 treatment Remdesivir.
gilead.com →Mammoth Biosciences
CRISPR Diagnostics
Co-founded by Nobel laureate Jennifer Doudna. Translating CRISPR technology into practical diagnostics and therapeutics.
mammothbio.com →Calico Life Sciences
Longevity Research
Alphabet's biotech focused on understanding and combating aging. Researching solutions to help people live longer, healthier lives.
calicolabs.com →Verily Life Sciences
Health-Tech Innovation
Alphabet's health-tech arm developing wearable sensors, clinical trial platforms, and bioinformatics. Bridging tech and healthcare.
verily.com →Vir Biotechnology
Infectious Disease
Combining immunologic insights with cutting-edge technology to treat infectious diseases including HIV, hepatitis B, and tuberculosis.
vir.bio →Tempus
Precision Medicine AI
Using AI and machine learning for precision medicine. Hosts world's largest library of clinical and molecular data for cancer research.
tempus.com →Helix
Genomics Platform
Working at intersection of biotech, genomics and clinical research. Enabling health systems to advance genetic research and drug development.
helix.com →ArsenalBio
T Cell Therapy
Raised $325M Series C in 2024. Advancing next-generation T cell therapies for solid tumors in partnership with Bristol Myers Squibb.
arsenalbio.com →Penumbra Inc.
Stroke Intervention
4,500+ employees, $1B+ revenue. Develops devices for neurovascular and peripheral clot removal - revolutionizing stroke treatment globally.
penumbrainc.com →Benchling
Biotech R&D Cloud
Mission to unlock the power of biotechnology. World's biotech leaders use Benchling R&D Cloud to accelerate time to milestone and market.
benchling.com →MBC BioLabs
Biotech Incubator
Premier biotech incubator bringing top minds together to create companies with widespread impacts on life sciences.
mbcbiolabs.com →Fintech & Financial Services
10 CompaniesStripe
Global Payments Infrastructure
World's largest private fintech. Processed $1.4 trillion in 2024 - 1.3% of global GDP. Powers payments for OpenAI, Amazon, and half of Fortune 100.
stripe.com →Plaid
Financial Data Connectivity
Raised $575M in 2025. Over half of Americans with bank accounts have used Plaid. Powers Venmo, Chime, Robinhood, and 8,000+ fintech apps.
plaid.com →Chime
Digital Banking
Fee-free digital banking for millions. Filed for IPO in December 2024. $1.67B revenue in 2024. Over 15 million customers.
chime.com →Block (Square)
Payment & Financial Services
Provides integrated commerce solutions through Square and Cash App. Leading payment processing for businesses and consumers nationwide.
block.xyz →Coinbase
Cryptocurrency Exchange
Dominant crypto trading platform with 110+ million users globally. Leading the way in cryptocurrency adoption and digital asset management.
coinbase.com →Affirm
Buy-Now-Pay-Later
Founded by PayPal co-founder Max Levchin. Transparent installment financing for online and in-store purchases. No hidden fees.
affirm.com →Brex
Corporate Finance Platform
Corporate card and expense management specifically designed for startups and growing businesses. Instant approvals, no personal guarantee.
brex.com →Ripple
Cross-Border Payments
Specializes in cross-border payments using blockchain technology. Enabling instant, low-cost international money transfers.
ripple.com →Robinhood
Commission-Free Trading
Democratizing finance for all. Commission-free stock, options, and crypto trading. Over 23 million funded accounts.
robinhood.com →Alpaca
Trading API Platform
Commission-free stock trading API. Backed by Spark Capital, Tribe Capital, Y Combinator. Enabling developers to build trading applications.
alpaca.markets →Venture Capital & Investment
10 FirmsSequoia Capital
Legendary VC Firm
Arguably the world's most famous VC. Early investors in Apple, Google, Instagram, WhatsApp, Stripe, Zoom. Partners with founders from idea to IPO.
sequoiacap.com →Andreessen Horowitz (a16z)
Tech Investment Powerhouse
Founded 2009, rapidly became one of the most influential VCs. Backed Facebook, Airbnb, Coinbase, OpenAI. Dominates AI, crypto, and biotech.
a16z.com →Kleiner Perkins
Silicon Valley Pioneer
"Perhaps Silicon Valley's most famous venture firm" - NYT. Invested in 900+ ventures including Amazon, Google, Twitter.
kleinerperkins.com →Accel
Global Venture Capital
Founded 1983. Backed Dropbox, Etsy, Slack, Spotify. Combines global reach with deep Silicon Valley roots in transformative technology.
accel.com →Benchmark
Early-Stage Focus
Pioneering equal-profit-share model. Backed eBay, Instagram, Twitter, Uber, Dropbox. High-conviction early-stage investments.
benchmark.com →Greylock Partners
Enterprise & Consumer
Top-tier firm backing entrepreneurs building defining new companies. Team includes operators from iconic tech companies.
greylock.com →Bessemer Venture Partners
Oldest US VC Firm
One of oldest and most respected VC firms. Expertise in cloud computing, cybersecurity. Backed LinkedIn, Shopify, Pinterest, DocuSign.
bvp.com →Y Combinator
World's Top Accelerator
Launched Airbnb, Stripe, Coinbase, DoorDash, Instacart. CEO Garry Tan driving SF's "boom loop" - over 2,000 Bay Area startups funded.
ycombinator.com →500 Global
Global Accelerator
One of world's most active VCs. Invested in 2,300+ companies. Mission to discover and back talented entrepreneurs worldwide.
500.co →Lightspeed Venture Partners
Multi-Stage VC
Premier multi-stage firm accelerating disruptive innovations. Early investor in Snap Inc. Deep domain expertise across sectors.
lsvp.com →Climate Tech & Clean Energy
10 CompaniesAurora Solar
Solar Design Software
One of nation's most valuable green-tech startups. Software powers top solar installers including SunPower. Expanded to Canada and Germany.
aurorasolar.com →Watershed
Carbon Management
Helps companies measure and reduce carbon emissions. Enterprise sustainability platform for climate action tracking and reporting.
watershed.com →Pachama
Forest Carbon Credits
Uses computer vision and satellites to drive funding to reforestation projects. Customers include Amazon, Airbnb, Netflix, Nespresso.
pachama.com →Noya
Carbon Capture
Radically reducing capital costs for direct air capture by retrofitting industrial cooling towers into CO2 capture machines.
noya.co →Elemental Excelerator
Climate Tech Accelerator
Global climate tech accelerator investing in energy, water, agriculture, and circular economy startups. Combines investment with hands-on support.
elementalexcelerator.com →Zitara Technologies
Battery Analytics
Tests battery performance for EVs, grid-scale storage, and satellites. Founded by Tesla veteran, connected with hundreds in renewable energy sector.
zitara.io →Bidirectional Energy
Vehicle-to-Grid Technology
Enabling electric vehicles to power homes and the grid. Founded by Angela Zhang - "no other place I'd rather be than San Francisco."
bidirectionalenergy.com →Ohmconnect
Demand Response
Home energy management via smart meter analytics. Enables residents to sell energy reductions directly into energy markets.
ohmconnect.com →First Solar
Solar Technology
Develops advanced solar technologies. Operates one of world's largest grid-connected solar power plants. 10% more energy than competitors.
firstsolar.com →Crusoe Energy Systems
Clean Computing Infrastructure
Converts energy from oil/gas operations into power for AI computing. Digital infrastructure that reduces waste and carbon footprint.
crusoe.ai →Wellness & Longevity
8 CompaniesBiohackr Health
Regenerative Medicine
Premier regenerative medicine practice. Specializes in hormone therapy, NAD+, anti-aging, and comprehensive health diagnostics.
biohackr.health →Frontier Tower (Viva.city)
Longevity Village
16-floor hub for longevity, AI, crypto, robotics. Features biohacking clinic, nootropics bar, biological age testing, hyperbaric oxygen.
viva.city →Mito Health
Preventive Health AI
YC-backed. Uses blood work and scans to prevent disease and extend lifespan. AI health expert in your pocket with trusted personalized advice.
mitohealth.com →Calm
Meditation & Sleep
Health technology startup for sleep, relaxation, and meditation. Mobile app helping millions improve mental wellness and sleep quality.
calm.com →MDalgorithms
AI Dermatology
Revolutionizing dermatology with AI-powered solutions for skin and hair care. Pioneer in machine-learning models for acne treatment since 2017.
mdalgorithms.com →Fella/Delilah
Metabolic Health
YC-backed. $50M+ ARR, cashflow positive. Sustainable weight loss medication expanding to hormonal health, mental health, longevity, primary care.
fellahealth.com →SmartSpot
AI Fitness Training
Backed by Founders Fund and Khosla Ventures. Uses computer vision to deliver unparalleled fitness training experience to your home.
smartspot.io →iRhythm Technologies
Cardiac Monitoring
Manufactures Zio, an ambulatory cardiac monitoring device with 14 days of uninterrupted monitoring. 90% success rate diagnosing irregular rhythms.
irhythmtech.com →Enterprise Software & SaaS
10 CompaniesSalesforce
CRM & Cloud Platform
World's #1 CRM platform. Headquartered in Salesforce Tower - SF's tallest building. Pioneer of cloud computing and enterprise software.
salesforce.com →ServiceNow
Digital Workflow Platform
Enterprise cloud computing platform for digital workflows. Automates IT service management across the enterprise.
servicenow.com →Zapier
Automation Platform
35% ARR growth with minimal funding. Connects 5,000+ apps for workflow automation. Massive surge in app integrations in 2024.
zapier.com →Airtable
No-Code Database Platform
Making software creation accessible to everyone. Cloud platform combining spreadsheet and database functionality for teams.
airtable.com →Slack
Team Communication
Enterprise messaging platform acquired by Salesforce for $27.7B. Transforms how teams collaborate and communicate.
slack.com →Zoom
Video Communications
Revolutionized video conferencing. Founded by former Cisco engineer Eric Yuan. Essential platform for remote work and virtual meetings.
zoom.us →DocuSign
Electronic Signatures
World leader in electronic signature technology. Transforms how agreements are prepared, signed, acted on, and managed.
docusign.com →Cloudflare
Web Performance & Security
Global cloud platform providing network services to businesses. Protects and accelerates websites, apps, and APIs.
cloudflare.com →Rubrik
Data Security Platform
Cloud data management and data security solutions. Protects enterprise data across cloud, edge, and on-premises environments.
rubrik.com →Mixpanel
Product Analytics
Business analytics platform that tracks user interactions with web and mobile applications. Helps teams build better products.
mixpanel.com →Consumer Tech & Marketplace
8 CompaniesAirbnb
Travel Marketplace
Revolutionized hospitality with home-sharing platform. 7M+ listings worldwide. Founded in SF apartment in 2008, now $80B+ company.
airbnb.com →DoorDash
Delivery Platform
Leading food delivery platform connecting customers with local restaurants in 600+ cities. Passionate about transforming local businesses.
doordash.com →Instacart
Grocery Delivery
North American leader in online grocery. Same-day delivery from local stores in as fast as one hour. Essential for millions of families.
instacart.com →Uber
Mobility Platform
Global mobility and delivery platform. Transformed transportation and on-demand delivery worldwide. One of SF's most iconic startups.
uber.com →Visual Discovery
Visual discovery engine for finding ideas. 450M+ monthly users discovering and saving creative inspiration worldwide.
pinterest.com →Discord
Community Platform
Messenger with voice and video for 270M+ users. From gaming to communities, businesses, and friends - Discord connects people.
discord.com →Faire
Wholesale Marketplace
Online marketplace using ML to match local retailers with brands. 7M+ new connections. Empowering local communities through retail.
faire.com →Flexport
Global Logistics
Licensed freight forwarder and shipping company managing global logistics. Technology platform simplifying international trade.
flexport.com →Speakers & Thought Leaders
12 LeadersSam Altman
CEO, OpenAI
Leading the AI revolution. Former Y Combinator president. Raised $40B in 2025 - largest venture round ever. Shaping the future of artificial intelligence.
Dario Amodei
CEO, Anthropic
Former OpenAI VP of Research. Leading AI safety research. Built Anthropic to $183B valuation with Constitutional AI approach.
Patrick Collison
CEO, Stripe
Irish-American entrepreneur. Built Stripe to $107B - world's largest private fintech. Processing 1.3% of global GDP.
Garry Tan
CEO, Y Combinator
Turning SF's "doom loop into a boom loop." Telling founders they "have to be in San Francisco." Driving Bay Area's tech renaissance.
Roelof Botha
Managing Partner, Sequoia Capital
Former PayPal CFO. Led investments in YouTube, Instagram, and dozens of unicorns. One of tech's most influential investors.
Marc Andreessen
Co-Founder, Andreessen Horowitz
Netscape co-founder. "Software is eating the world." One of the most influential voices in technology and venture capital.
Jeff Maggioncalda
CEO, Coursera
Grew Coursera to 142M+ learners and 7,000+ institutions. Former Financial Engines CEO. Stanford MBA. Expert in education technology.
Jonathan Ross
CEO & Founder, Groq
Designed Google's first TPU as a 20% project. Founded Groq to create world's first Language Processing Unit for AI inference.
Amjad Masad
CEO, Replit
Jordanian-American entrepreneur. Built Replit into fastest-growing developer community. Former Facebook engineer, Codecademy co-founder.
Aubrey de Grey
Longevity Research Pioneer
Leading voice in aging research. Speaker at SF's Frontier Tower longevity summit. Advocates for treating aging as a medical condition.
Bill Tai
Venture Capitalist & Advisor
Funding startups since 1991. 20+ seed-stage companies grew to public listings. Investor in Canva, Zoom, and CNBC Disruptive Companies.
Guy Kawasaki
Chief Evangelist & Author
Former Apple Chief Evangelist. Bestselling author and speaker. Legendary figure in Silicon Valley marketing and entrepreneurship.
Education & Research
6 InstitutionsStanford University
Research University
Birthplace of Silicon Valley. Spawned Google, HP, Yahoo, LinkedIn, and countless startups. $1.5B in NIH funding with UCSF.
stanford.edu →UC San Francisco
Health Sciences University
Leading health sciences university. $1.5B in NIH funding (combined with Stanford). Driving medical innovation and biotech talent.
ucsf.edu →UC Berkeley
Research University
Top public university. Talent powerhouse for East Bay life sciences. CRISPR co-inventor Jennifer Doudna's home institution.
berkeley.edu →Techstars San Francisco
Startup Accelerator
Premier accelerator in world's startup hub. Launching pad for ambitious founders with cutting-edge solutions.
techstars.com →Gladstone Institutes
Biomedical Research
Institute of Data Science and Biotechnology. Collaboration of data scientists, tech creators, and biologists pushing groundbreaking science.
gladstone.org →Berkeley SkyDeck
UC Berkeley Accelerator
Investment partner for UC Berkeley's accelerator program. $100K into each startup. One of most active seed investors in Bay Area.
skydeck.berkeley.edu →